- Title
- GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer
- Creator
- Chen, Maxine M.; O'Mara, Tracy A.; Cheng, Timothy H. T.; Cook, Linda S.; Crous-Bou, Marta; Doherty, Jennifer; Friedenreich, Christine M.; Garcia-Closas, Montserrat; Gaudet, Mia M.; Gorman, Maggie; Haiman, Christopher; Hankinson, Susan E.; Thompson, Deborah J.; Holliday, Elizabeth G.; Painter, Jodie N.; Australian National Endometrial Cancer Study Group (ANECS),; Attia, John; Black, Amanda; Brinton, Louise; Chanock, Stephen; Chen, Chu
- Relation
- NHMRC.339435; NHMRC.552402 & NHMRC.1031333 http://purl.org/au-research/grants/nhmrc/1031333
- Relation
- Human Molecular Genetics Vol. 25, Issue 12, p. 2612-2620
- Publisher Link
- http://dx.doi.org/10.1093/hmg/ddw092
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2016
- Description
- Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 x 10−8) at 6p22.3 (rs1740828; P = 2.29 x 10−8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.
- Subject
- endometrial cancer; genetic predisposition to disease; genome; single nucleotide polymorphism; gynecologic cancer; genetic risk; genome-wide association study
- Identifier
- http://hdl.handle.net/1959.13/1338005
- Identifier
- uon:27911
- Identifier
- ISSN:0964-6906
- Language
- eng
- Reviewed
- Hits: 17591
- Visitors: 8795
- Downloads: 0
| Thumbnail | File | Description | Size | Format |
|---|